Database : HANSEN Search on : CELULAS DE SCHWANN/PATOL [Subject descriptor] References found : 6 [refine] Displaying: 1 .. 6   in format [Detailed]

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Id: 13790 Author: Hagge, Deanna A; Robinson, Sandra Oby; Scollard, David; McCormick, Gregory; Williams, Diana L Title: A new model for studyng the effects of Mycobacterium leprae on Schwann cell and neuron interactions ..- Source: s.l; s.n; 2002. 14 p. ilus, tab. Abstract: Millions of patients with leprosy suffer from nerve damage resulting in disabilities as a consequence of Mycobacterium leprae infection. However, mechanisms of nerve damage have not been elucidated because of the lack of a model that maintains M. leprae viability and mimics disease conditions. A model was developed using viable M. leprae, rat Schwann cells, and Schwann cell-neuron cocultures incubated at 33 degrees C. M. leprae retained 56 per cente viability in Schwann cells for 3 weeks after infection at 33 degrees C, compared with 3.6 per cente viability at 37 degrees C. Infected Schwann cells had altered morphology and expression of genes encoding cellular adhesion molecules at 33 degrees C but were capable of interacting with and myelinating neurons. Cocultures, infected after myelination occurred, showed no morphological changes in myelin architecture after 1 month of incubation at 33 degrees C, and M. leprae retained 53 per cente viability. This article describes a new model for studying the effects of M. leprae on Schwann cells. (AU). Descriptors: CAMUNDONGOS NUS HANSENIASE/microbiol HANSENIASE/patol MODELOS NEUROLOGICOS MICROSCOPIA ELETRÔNICA DE VARREDURA CELULAS CULTIVADAS NEURÔNIOS/microbiol NEURÔNIOS/patol NEURÔNIOS/fisiol COMUNICACAO CELULAR/fisiol MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol CELULAS DE SCHWANN/microbiol CELULAS DE SCHWANN/patol CELULAS DE SCHWANN/fisiol CELULAS DE SCHWANN/ultraest Limits: HUMANO ANIMAL CAMUNDONGOS RATOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09030/s

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Id: 13732 Author: Oliveira, Rosane B; Ochoa, Maria T; Sieling, Peter A; Rea, Thomas H; Rambukkana, Anura; Sarno, Euzenir N; Modlin, Robert L Title: Expression of toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy ..- Source: s.l; s.n; 2003. 7 p. ilus, graf. Abstract: Nerve damage is a clinical hallmark of leprosy and a major source of patient morbidity. We investigated the possibility that human Schwann cells are susceptible to cell death through the activation of Toll-like receptor 2 (TLR2), a pattern recognition receptor of the innate immune system. TLR2 was detected on the surface of human Schwann cell line ST88-14 and on cultured primary human Schwann cells. Activation of the human Schwann cell line and primary human Schwann cell cultures with a TLR2 agonist, a synthetic lipopeptide comprising the N-terminal portion of the putative Mycobacterium leprae 19-kDa lipoprotein, triggered an increase in the number of apoptotic cells. The lipopeptide-induced apoptosis of Schwann cells could be blocked by an anti-TLR2 monoclonal antibody. Schwann cells in skin lesions from leprosy patients were found to express TLR2. It was possible to identify in the lesions Schwann cells that had undergone apoptosis in vivo. The ability of M. leprae ligands to induce the apoptosis of Schwann cells through TLR2 provides a mechanism by which activation of the innate immune response contributes to nerve injury in leprosy. (AU). Descriptors: APOPTOSE CELULAS CULTIVADAS DANO DO DNA IMUNIDADE NATURAL HANSENIASE/imunol HANSENIASE/patol LIPOPROTEINAS/fisiol CELULAS DE SCHWANN/patol GLICOPROTEINAS DE MEMBRANA/anal GLICOPROTEINAS DE MEMBRANA/fisiol RECEPTORES DA SUPERFICIE CELULAR/anal RECEPTORES DA SUPERFICIE CELULAR/fisiol Limits: HUMANO SUPPORT, NON-U.S. GOV'T SUPPORT, U.S. GOV'T, P.H.S Electronic Medium: http://www.ilsl.br Location: BR191.1; 09028/s

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Id: 13530 Author: Hagge, Deanna; Robinson, Sandra Oby; Scollard, David; McCormick, Gregory; Williams, Diana L Title: A new model for studying the effects of Mycobacterium leprae on Schwann cell and neuron interactions ..- Source: s.l; s.n; 2002. 4 p. tab. Abstract: Millions of patients with leprosy suffer from nerve damage resulting in disabilities as a consequence of Mycobacterium leprae infection. However, mechanisms of nerve damage have not been elucidated because of the lack of a model that maintains M. leprae viability and mimics disease conditions. A model was developed using viable M. leprae, rat Schwann cells, and Schwann cell-neuron cocultures incubated at 33 degrees C. M. leprae retained 56% viability in Schwann cells for 3 weeks after infection at 33 degrees C, compared with 3.6% viability at 37 degrees C. Infected Schwann cells had altered morphology and expression of genes encoding cellular adhesion molecules at 33 degrees C but were capable of interacting with and myelinating neurons. Cocultures, infected after myelination occurred, showed no morphological changes in myelin architecture after 1 month of incubation at 33 degrees C, and M. leprae retained 53% viability. This article describes a new model for studying the effects of M. leprae on Schwann cells. (AU). Descriptors: COMUNICACAO CELULAR/fisiol CELULAS CULTIVADAS HANSENIASE/microbiol HANSENIASE/patol CAMUNDONGOS NUS MODELOS NEUROLOGICOS NEURÔNIOS/microbiol NEURÔNIOS/patol NEURÔNIOS/fisiol CELULAS DE SCHWANN/microbiol CELULAS DE SCHWANN/patol CELULAS DE SCHWANN/fisiol CELULAS DE SCHWANN/ultraest MICROSCOPIA ELETRÔNICA DE VARREDURA MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol Limits: ANIMAL HUMANO CAMUNDONGOS RATOS SUPPORT, NON-U.S. GOV'T Location: BR191.1; 08982/s

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Id: 12262 Author: Spierings, Eric; Boer, Tjitske de; Wieles, Brigitte; Adams, Linda B; Marani, Enrico; Ottenhoff, Tom H. M Title: Mycobacterium leprae-specific, HLA class II- restricted killing of human Schwann cells by CD4+ Th1 cells: a novel immunopathogenic mechanism of nerve damage in leprosy ..- Source: s.l; s.n; 2001. 6 p. ilus, tab, graf. Descriptors: APRESENTAÇAO DO ANTIGENO ANTIGENOS DE BACTÉRIAS ANTIGENOS DE BACTÉRIAS CÉLULAS CLONAIS CITOTOXICIDADE IMUNOLOGICA MAPEAMENTO DE EPITOPOS EPITOPOS DE LINFOCITO T ANTIGENOS HLA-D IMUNOFENOTIPAGEM HANSENIASE HANSENIASE HANSENIASE CAMUNDONGOS MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS TH1 CÉLULAS TH1 CÉLULAS TH1 Location: BR191.1; 08693/s

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Id: 11316 Author: Shimoji, Yoshihiro; Ng, Vincent; Matsumura, Kiichiro; Fischetti, Vincent A; Rambukkana, Anura Title: A 21-kDa surface protein of mycobacterium leprae binds peripheral nerve laminin-2 and mediates Schwann cell invasion ..- Source: s.l; s.n; 1999. 6 p. tab, graf. Descriptors: SEQUENCIA DE AMINOACIDOS ADESINAS BACTERIANAS ADESINAS BACTERIANAS SEQUENCIA DE BASES ELETROFORESE EM GEL DE POLIACRILAMIDA LAMININA HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C MICROSCOPIA IMUNOELETRONICA DADOS DE SEQUENCIA MOLECULAR PESO MOLECULAR MYCOBACTERIUM LEPRAE SISTEMA NERVOSO PERIFÉRICO SISTEMA NERVOSO PERIFÉRICO CÉLULAS DE SCHWANN PROPRIEDADES DE SUPERFICIE CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07255/s

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Id: 10270 Author: Singh, Neeta; Birdi, Tannaz J; Antia, Noshir H Title: Differential in vitro modulation of schwann cell proliferation by mycobacterium leprae and macrophages in the murine strains, Swiss white and C57BI/6 ..- Source: s.l; s.n; 1998. 10 p. tab, graf. Descriptors: DIVISAO CELULAR COCULTURA HANSENIASE MACROFAGOS CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS C57BL MYCOBACTERIUM LEPRAE CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CÉLULAS DE SCHWANN CELULAS CULTIVADAS Limits: ANIMAL Location: BR191.1; 07165/s

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